• [5] Design a microfluidic chip to separate CTCs.

Figure: Separation of CTCs, RBC (red blood cell), WBC (white blood cell) and CTC (circulating tumor cell).

• [4] Investigate the behaviors of a large number of cells through a microvascular network. 

Figure: Motion of a large number of cells in a microvascular network.

• [3] Investigate the behaviors of cells through microtubes with a thrombus.

Figure: Cells passing through curved (a) and bifurcated (b) tubes with a thrombus.              

• [2] Investigate the motion, deformation and aggregation of a single cell or multiple cells in complex microtubes. 

Figure：A cell in a rectangular (a), cylindrical (b), curved (c), constricted (d), spiral (e) and bifurcated (f) tubes, respectively.

• [1] Develop cell mechanical model, and study the motion, deformation and aggregation of several cells in simple microtubes. 

Figure:  (a) Stretching of a cell, (b) tumbling motion of a cell in shear flow, (c) two cells in tube flow, (d) a file of cells in tube flow.